In this session at the ESC Congress 2025 the presenters discussed the progress in advanced heart failure therapy.

The analysis and reduction of risk factors for ventricular arrhythmias are highlighted in this ESC Congress 2025 session.

An 18-year follow-up of 175 adults with systemic lupus erythematosus revealed that CKD affected 54.6% of patients, including those without a history of lupus nephritis (LN, 46.1%). LN emerged as a strong predictor of CKD (HR 5.4), alongside age and lower eGFR at diagnosis. They also exhibited higher CV morbidity, hospitalization rates for SLE exacerbations and infections, and mortality (19.1% vs 1.4% without CKD).

A study of 1,157 participants found that girls experiencing dysmenorrhea at age 15 had an increased risk of chronic pain by age 26. Moderate dysmenorrhea raised risk by 65% (RR 1.65) and severe by 76% (RR 1.76), corresponding to absolute risk increases of 12.7 and 16.2 percentage points vs. those with no menstrual pain. Early recognition and effective management could reduce long-term chronic pain risk.

Melanoma survivors had elevated risk of developing prostate (HR 1.13), lung (1.55), kidney (1.50), uterine (1.30), thyroid (2.09), and breast cancer (1.23) compared to nonmelanoma skin cancer survivors. Survival also differed, with worse outcomes in those with a history of melanoma for prostate, lung, colorectal, kidney, uterine, pancreatic, thyroid, and breast cancer.

Adults diagnosed with T2DM at age 18-39 faced markedly higher risk of CKD (HR 1.87), renal decline (4.87), and end-stage renal disease (4.49) vs. non-diabetic peers, according to two cohort studies. Risks declined with older onset, dropping to 1.26, 1.66, and 1.48 in those ≥80 years. The findings highlight the need for early detection, close monitoring, and renal-protective strategies in younger T2DM adults.