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14 Aug, 26
Obesity is a chronic, complex disease. Guidelines from the ADA’s Obesity Association, recommend annual screening with BMI, ethnicity-specific diagnostic criteria, waist circumference assessment, & comprehensive staging to guide personalized care.
14 Aug, 26
The ESPID Clinical Practice Guidelines recommend penicillins as first-line treatment for pediatric Group A Streptococcal (iGAS) infections, with the addition of clindamycin for toxin-mediated cases.
17 Aug, 26
Hypertension.
- In ARIC visit 10863 adults (mean age 83.7 yrs) underwent supine & standing BP measurements, initial OH (SBP drop ≥20 mmHg or DBP drop ≥10 mmHg immediately after standing) was seen in 41.3%
- Initial & early OH were linked to orthostatic symptoms (OR 2.34, OR 1.82), while initial OH raised fall rates (RR 1.45)
- BP assessment within 3 mins, especially immediately after standing, best identified clinically relevant OH.
14 Aug, 26Cardiovasc Diabetol.
- In a Finnish cohort of 4215 T1DM patients, 449 1st MIs were identified
- STEMI risk was lower with higher ApoA-I (HR 0.77, 95% CI 0.60-0.99), HDL2-C (HR 0.72, 0.55-0.95), & HDL-C/TC ratio (HR 0.76, 0.59-0.98)
- NSTEMI risk increased with ApoB-100 (HR 1.31, 1.15-1.50) & ApoB/ApoA-I ratio (HR 1.29, 1.18-1.41)
- Higher eGDR reduced STEMI (HR 0.82) & NSTEMI (HR 0.92) risk
- Lipid risk profiles differed between MI subtypes.
12 Aug, 26Obesity Med.
- In a case-control study of 176 young adults in Southern India (88 with obesity, 88 controls), obesity was associated with higher insulin resistance (HOMA-IR 5.5 vs 4.3; p=0.005) & IL-6 levels (10.1 vs 5.0 pg/mL; p<0.001)
- BMI & WHtR showed weak correlations with metabolic & inflammatory biomarkers, suggesting HOMA-IR & IL-6 may better identify early cardiometabolic risk than anthropometry alone.
12 Aug, 26Am J Obstet Gynecol
- Among 493 women with persistent high-risk HPV and normal or low-grade cytology, 17.8% had histologically confirmed high-grade squamous intraepithelial lesion, with higher risk in younger women and those with atypical squamous cell of undetermined significance cytology
- Colposcopy and Swedescore showed high specificity but low sensitivity, missing many lesions, highlighting a low threshold for biopsy in this group.
13 Aug, 26
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