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7 Oct, 26
WHO-recommended Low Osmolarity ORS (LORS) is the standard and most effective solution for managing dehydration in children, reducing stool output, vomiting, and the need for IV fluids. The paper emphasizes improving awareness, accessibility, and adoption of LORS, to ensure consistent use of WHO-compliant formulations.
30 Sep, 26
The updated guideline for stage I-III HER2-positive, HER2-negative breast cancer emphasizes endocrine therapy as the treatment foundation, with chemotherapy & targeted therapies tailored by clinical features, genomic risk & treatment tolerance.
8 Oct, 26
ESC Heart Fail.
- Amongst 109,909 HFpEF patients, 26%-70% had WHO-defined anemia
- Anemia was independently associated with higher all-cause mortality: aHR 1.49 (95% CI 1.35-1.66; I²=85%) for LVEF ≥40% & aHR 1.41 (95% CI 1.26-1.57; I²=83%) for LVEF ≥50%
- Each 1 g/dL decrease in hemoglobin increased mortality risk by 17% (aHR 1.17)
- Anemia may improve risk tratification in HFpEF; trials are warranted to confirm the finding.
7 Oct, 26Obesity Facts.
- Analysis of GBD 2023 data showed East Asia had the highest childhood asthma burden attributable to high BMI in 2023 (CDR 16.28/100,000), with the greatest increase since 1990 (EAPC 1.57%/year) & projected growth to 2050 (EAPC 4.49%/year)
- South Asia had the lowest CDR (1.94/100,000)
- CDR correlated positively with SDI (ρ=0.54; P<0.001), with a greater rise among girls.
6 Oct, 26
A 37-year-old man with T1DM and ESKD on peritoneal dialysis had resistant hypertension despite multiple antihypertensives. BP remained uncontrolled despite treatment adjustments. Click here to know how the case was managed.
5 Oct, 26Diabetes Obes Metab.
- In 192 patients with T2DM without overt HF, NT-proBNP levels increased with worsening renal function (204.3 vs 96.8 vs 62.2 pg/mL across eGFR 30-59, 60-89 & ≥90 mL/min/1.73 m²; p<0.001)
- NT-proBNP correlated with albuminuria (uACR; r=0.31, p<0.001) but not FMD (p=0.388)
- Older age (aOR 1.14), higher SBP (aOR 1.05), lower eGFR (aOR 0.97), & beta-blocker use (aOR 4.65) independently predicted elevated NT-proBNP.
29 Sep, 26
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